RESUMO
Rokitansky and Langhans first reported multinucleated giantcells in tuberculous granulomas around a century ago. Inprocess of tissue remodeling and repair the multinucleatedgiant cells (MGCs) acts as inextricable mediators. They alsoaid in removal of various pathogens and foreign materials(Vignery, 2005). Thus, for host survival they have a rolein elimination of foreign substances, damaged tissue, andpathogens. Giant cells are supposed to arise from the monocyteprecursors which forms subsequently to various mechanisms.These cells assume distinctly variable phenotypes dependingupon the mechanism of their formation. This review focuseson the role of the giant cell in oral pathoses such as microbiallesions, cystic lesions, metabolic lesions and cancer.
RESUMO
Smoking is a taboo, and a smoker fails in quitting despite repeated attempts as tobacco in all forms contain a highly addictive chemical nicotine making it difficult for habituated tobacco users to quit. Its addictive potential is considered to be even more than cocaine or heroin. It is due to the dependency caused by the nicotine that smokers become dependent and cause severe withdrawal symptoms. Hence, nicotine replacement therapy came into play to aid in tobacco cessation. There are currently various nicotine replacement therapies, which are available currently for tobacco abstinence. In this article, we shall discuss nicotine nasal spray, mouth spray, and the nicotine inhaler.